![]() ![]() The results showed that this spore-based probiotic The same meal was provided at the end of the study to assess Responders were selected after consuming a high-fat mealįrom thin-crust cheese pizza (approximately 1600 calories and 89 g ofįat) and randomized to receive either Megaspore or placebo for 30 days. Investigating the effect of 2 capsules per day (4 billion CFU total) was Small 2017 study with 28 young healthy men and women responders Investigate the effect of Megaspore probiotic on leaky gut syndrome, a Hours after consuming a high fat, high calorie meal. Who experience at least a 5-fold increase in dietary endotoxemia within 5 One-third (1/3) of people in Western society do. The meal, but estimates from one proof-of-concept study showed that NotĮveryone who consumes such a meal experiences an exaggerated response to High-calorie meal was associated with increases in serum (blood)Įndotoxins, triglycerides, and various inflammatory markers. Researchers have demonstrated that consumption of one high-fat, Transient increases in systemic (body-wide) inflammation. Permeability (AKA leaky gut), the microbiota, or both, and causes It is a sign that of a disruption in intestinal So, does this supplement do that? Let’s look at research recently published.Įndotoxemia is a phenomenon in which blood levels of endotoxins Does MegaSporeBiotic Recondition the Gut? Research on a product as a whole is the best indicator of why we can expect from it. You can see that the research on this product is exploding, which is super helpful to know for what conditions this product is effective. ![]() Here is a sampling of subjects of clinical trials, pilot studies, and other research that Microbiome Labs has planned or will soon publish (I will update this page accordingly): Now I am so very pleased to see that there are studies with this product in human clinical trials and with some of the strains in a dog clinical trial! (Yes, dogs get leaky gut, too!) And, very excitingly, there are many more clinical studies nearing completion, in progress, and being planned. Some of them stimulated the immune system, some of them produced vitamins, one produced carotenoids…but how would they act together in a digestive tract? Still, it was hard to discern how these combined strains would act in a human. As time passed, studies with some of the individual strains in a simulated human intestinal environment, SHIME (simulator of the human intestinal microbial ecosystem) were performed, showing more potential. In the past, when research studies on the probiotic strains in this product were first published, there weren’t studies I could find beyond petri dish and animal studies with one or maybe two of the strains. If you haven't read my overview of Bacillus species, then I recommend that you do that before delving into the specifics about this product so that you understand how Bacillus bacteria act in your digestive tract. What Does Research Show About These MegaSporeBiotic Bacteria? Which Probiotic Strains are in MegaSporeBiotic? It is manufactured for Microbiome Labs in Saint Augustine, Florida, USA, and is part of their Total Gut Restoration program. It is marketed as a "probiotic and antioxidant combination." MegaSporeBiotic is an all- Bacillus species, pharmaceutical-grade probiotic supplement with 5 different species in it. ![]()
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